Precision-cut tissue chips as an in vitro toxicology system
نویسندگان
چکیده
منابع مشابه
Assessment of immunotoxicity using precision-cut tissue slices
1.When the immune system encounters incoming infectious agents, this generally leads to immunity. The evoked immune response is usually robust, but can be severely perturbed by potentially harmful environmental agents such as chemicals, pharmaceuticals and allergens. 2.Immunosuppression, hypersensitivity and autoimmunity may occur due to changed immune activity. Evaluation of the immunotoxic po...
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BACKGROUND The therapeutic effect of inhaled corticosteroids (ICS) may be affected by the metabolism of the drug in the target organ. We investigated the in vitro metabolism of beclomethasone dipropionate (BDP), budesonide (BUD), ciclesonide (CIC), and fluticasone propionate (FP) in human lung precision-cut tissue slices. CIC, a new generation ICS, is hydrolyzed by esterases in the upper and lo...
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 2007
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2007.02.001